Prof. Dr. Anna Seelig

Seelig, J. and Seelig, A. (2023) “Protein Unfolding-Thermodynamic Perspectives and Unfolding Models”, International journal of molecular sciences, 24(6), p. 5457. 10.3390/ijms24065457.   edoc | Open Access
 

Seelig, A. and Li-Blatter, X. (2023) “P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport”, Cancer Drug Resistance, 6, pp. 1–29. 10.20517/cdr.2022.59.   edoc | Open Access
 

Seelig, J. and Seelig, A. (2022) “Protein unfolding. Thermodynamic perspectives and unfolding models”. bioRxiv. 10.1101/2022.11.08.515403.   edoc | Open Access
 

Seelig, J. and Seelig, A. (2021) “Molecular Understanding of Calorimetric Protein Unfolding Experiments”, Biophysical Reports, 2(1), p. 100037. 10.1016/j.bpr.2021.100037.   edoc | Open Access
 

Seelig, A. (2020) “P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers”, Frontiers in Oncology, 10, p. 576559. 10.3389/fonc.2020.576559.   edoc | Open Access
 

Assmus, F., Ross, A., Fischer, H., Seelig, J. and Seelig, A. (2017) “(31)P and (1)H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay”, Molecular Pharmaceutics, 14(1), pp. 284–295. 10.1021/acs.molpharmaceut.6b00889.   edoc
 

Xu, Y., Seelig, A. and Bernèche, S. (2017) “Unidirectional Transport Mechanism in an ATP Dependent Exporter”, ACS Central Science, 3(3), pp. 250–258. 10.1021/acscentsci.7b00068.   edoc | Open Access
 

Zwick, M., Esposito, C., Hellstern, M. and Seelig, A. (2016) “Interplay between CFTR Phosphorylation, CFTR-ATPase Activity, and Anion Flux”, Journal of Biological Chemistry, 291(28), pp. 14483–14498. 10.1074/jbc.M116.721415.   edoc | Open Access
 

Assmus, F., Seelig, A., Gobbi, L., Borroni, E., Glaentzlin, P. and Fischer, H. (2015) “Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates”, European journal of pharmaceutical sciences, 79, pp. 27–35. 10.1016/j.ejps.2015.08.014.   edoc
 

Egido, E., Müller, R., Li-Blatter, X., Merino, G. and Seelig, A. (2015) “Predicting Activators and Inhibitors of the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1) Based on Mechanistic Considerations”, Molecular pharmaceutics, 12(11), pp. 4026–4037. 10.1021/acs.molpharmaceut.5b00463.   edoc
 

Wagner, B., Fischer, H., Kansy, M., Seelig, A. and Assmus, F. (2015) “Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients”, European journal of pharmaceutical sciences, 68, pp. 68–77. 10.1016/j.ejps.2014.12.009.   edoc
 

Zolnerciks, J. K., Akkaya, B. G., Snippe, M., Chiba, P., Seelig, A. and Linton, K. J. (2014) “The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle”, FASEB Journal, 28(10), pp. 4335–4346. 10.1096/fj.13-245639.   edoc
 

Beck, A., Aanismaa, P., Li-Blatter, X., Dawson, R., Locher, K. P. and Seelig, A. (2013) “SAV1866 from Staphylococcus aureus and P-Glycoprotein – Similarities and Differences in ATPase Activity Assessed with Detergents as Allocrites”, Biochemistry, Vol. 52, H. 19 , S. 3297–3309. 10.1021/bi400203d.   edoc
 

Marzolini, C., Mueller, R., Li-Blatter, X., Battegay, M. and Seelig, A. (2013) “The Brain Entry of HIV-1 Protease Inhibitors Is Facilitated When Used in Combination”, Molecular Pharmaceutics, 10(6), pp. 2340–2349. 10.1021/mp300712a.   edoc
 

Barrera, B., Otero, J. A., Egido, E., Prieto, J. G., Seelig, A., Alvarez, A. I. and Merino, G. (2012) “The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP”, Antimicrobial Agents and Chemotherapy, 56(7), pp. 3535–3543. 10.1128/AAC.06345-11.   edoc
 

Li-Blatter, X., Beck, A. and Seelig, A. (2012) “P-glycoprotein-ATPase modulation: the molecular mechanisms”, Biophysical journal, Vol. 102, H. 6, pp. 1383–1393. 10.1016/j.bpj.2012.02.018.   edoc
 

Li-Blatter, X. and Seelig, A. (2010) “Exploring the p-glycoprotein binding cavity with polyoxyethylene alkyl ethers”, Biophysical Journal, 99(11), pp. 3589–3598. 10.1016/j.bpj.2010.10.033.   edoc
 

Nervi, P., Li-Blatter, X., Aanismaa, P. and Seelig, A. (2010) “P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity”, Biochimica et biophysica acta, Vol. 1798, pp. 515–525. 10.1016/j.bbamem.2009.11.022.   edoc
 

Beck, A., Li-Blatter, X., Seelig, A. and Seelig, J. (2010) “On the Interaction of Ionic Detergents with Lipid Membranes : Thermodynamic Comparison of n-Alkyl-+N(CH3)3 and n-Alkyl-SO4-”, Journal of Physical Chemistry B, 114(48), pp. 15862–15871. 10.1021/jp107088d.   edoc
 

Seelig, A. (2009) “Toward understanding P-glycoprotein structure-activity relationships”, in Drug bioavailability. Weinheim: Wiley-VCH, pp. 497–519.   edoc
 

Li-Blatter, X., Nervi, P. and Seelig, A. (2009) “Detergents as intrinsic P-glycoprotein substrates and inhibitors”, Biochimica et biophysica acta, 1788(10), pp. 2335–2344. 10.1016/j.bbamem.2009.07.010 .   edoc
 

Aanismaa, P., Gatlik-Landwojtowicz, E. and Seelig, A. (2008) “P-glycoprotein senses its substrates and the lateral membrane packing density : consequences for the catalytic cycle”, Biochemistry, Vol. 47, H. 38, pp. 10197–10207.   edoc
 

Turunen, B. J., Ge, H., Oyetunji, J., Desino, K. E., Vasandani, V., Guthe, S., Himes, R. H., Audus, K. L., Seelig, A. and Georg, G. I. (2008) “Paclitaxel succinate analogs : anionic and amide introduction as a strategy to impart blood-brain barrier permeability”, Bioorganic & medicinal chemistry letters, Vol. 18, pp. 5971–5974.   edoc
 

Aanismaa, P. and Seelig, A. (2007) “P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells”, Biochemistry, Vol. 46, H. 11, pp. 3394–3404.   edoc
 

Seelig, A. (2007) “The role of size and charge for blood-brain barrier permeation of drugs and fatty acids”, Journal of Molecular Neuroscience, 33(1), pp. 32–41. 10.1007/s12031-007-0055-y.   edoc | Open Access
 

Gatlik-Landwojtowicz, E., Aanismaa, P. and Seelig, A. (2006) “Quantification and characterization of P-glycoprotein-substrate interactions”, Biochemistry, Vol. 45, H. 9, pp. 3020–3032.   edoc
 

Gerebtzoff, G. and Seelig, A. (2006) “In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter”, Journal of Chemical Information and Modeling, Vol. 46, H. 6, pp. 2638–2650.   edoc
 

Seelig, A. and Gerebtzoff, G. (2006) “Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding”, Expert Opinion on Drug Metabolism & Toxicology, Vol. 2, H. 5, pp. 733–752.   edoc
 

Seelig, A. (2006) “Unraveling membrane-mediated substrate-transporter interactions”, Biophysical journal, Vol. 90, H. 11, pp. 3825–3826.   edoc
 

Ge, H., Vasandani, V., Huff, J. K., Audus, K. L., Himes, R. H., Seelig, A. and Georg, G. I. (2006) “Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells”, Bioorganic & medicinal chemistry letters, Vol. 16, H. 2, pp. 433–436.   edoc
 

Spletstoser, J. T., Turunen, B. J., Desino, K., Rice, A., Datta, A., Dutta, D., Huff, J. K., Himes, R. H., Audus, K. L., Seelig, A. and Georg, G. I. (2006) “Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells”, Bioorganic & medicinal chemistry letters, Vol. 16, H. 3, pp. 495–498.   edoc
 

Meier, M., Blatter, X. L., Seelig, A. and Seelig, J. (2006) “Interaction of verapamil with lipid membranes and P-glycoprotein : connecting thermodynamics and membrane structure with functional activity”, Biophysical journal, Vol. 91, H. 8, pp. 2943–2955. 10.1529/biophysj.106.089581.   edoc
 

Seelig, A. and Gatlik-Landwojtowicz, E. (2005) “Inhibitors of multidrug efflux transporters : their membrane and protein interactions”, Mini Reviews in Medicinal Chemistry, 5(2), pp. 135–151. 10.2174/1389557053402693.   edoc
 

Green, J. D., Kreplak, L., Goldsbury, C., Li Blatter, X., Stolz, M., Cooper, G. S., Seelig, A., Kistler, J. and Aebi, U. (2004) “Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide”, Journal of molecular biology, Vol. 342, H. 3, pp. 877–887.   edoc
 

Seelig, A. (2004) “Screening for multidrug resistance”, Screening, Vol. 4, pp. 20–21.   edoc
 

Gerebtzoff, G., Li-Blatter, X., Fischer, H., Frentzel, A. and Seelig, A. (2004) “Halogenation of drugs enhances membrane binding and permeation”, ChemBioChem, Vol. 5, H. 5, pp. 676–684.   edoc
 

Gatlik-Landwojtowicz, E., Aanismaa, P. and Seelig, A. (2004) “The rate of P-glycoprotein activation depends on the metabolic state of the cell”, Biochemistry, Vol. 43, H. 46, pp. 14840–14851.   edoc
 

Seelig, A., Gatlik, E., Fischer, H. and Li-Blatter, X. (2003) “Towards P-glycoprotein structure-activity relationships”, in Drug bioavailability. Weinheim: Wiley-VCH, pp. 461–492.   edoc
 

Ziegler, A., Blatter, X. L., Seelig, A. and Seelig, J. (2003) “Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles : binding mechanism and thermodynamic analysis”, Biochemistry, Vol. 42, H. 30, pp. 9185–9194. 10.1021/bi0346805.   edoc
 

Seelig, A. and Seelig, J. (2002) “Membrane structure”, in Encyclopedia of physical science and technology. San Diego: Academic Press, pp. 355–367.   edoc
 

Landwojtowicz, E., Nervi, P. and Seelig, A. (2002) “Real-time monitoring of P-glycoprotein activation in living cells”, Biochemistry, Vol. 41, H. 25, pp. 8050–8057.   edoc
 

Seelig, A., Blatter, X. L. and Wohnsland, F. (2000) “Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1 : a comparison”, International Journal of Clinical Pharmacology and Therapeutics, 38(3), pp. 111–121. 10.5414/CPP38111.   edoc
 

Seelig, A., Blatter, X. L., Frentzel, A. and Isenberg, G. (2000) “Phospholipid binding of synthetic talin peptides provides evidence for an intrinsic membrane anchor of talin”, Journal of Biological Chemistry, 275(24), pp. 17954–17961. 10.1074/jbc.M002264200.   edoc | Open Access
 

Seelig, A. and Landwojtowicz, E. (2000) “Structure-activity relationship of P-glycoprotein substrates and modifiers”, European journal of pharmaceutical sciences, Vol. 12, H. 1, pp. 31–40.   edoc
 

Zurbriggen, R., Novak-Hofer, I., Seelig, A. and Gluck, R. (2000) “IRIV-adjuvanted hepatitis A vaccine : in vivo absorption and biophysical characterization”, Progress in Lipid Research, 39(1), pp. 3–18. 10.1016/S0163-7827(99)00017-X.   edoc
 

Andre, J. P., Toth, E., Fischer, H., Seelig, A., Macke, H. R. and Merbach, A. E. (1999) “High relaxivity for monomeric Gd(DOTA)-based MRI contrast agents, thanks to micellar self-organization”, Chemistry, Vol. 5, no. 10, pp. 2977–2983.   edoc
 

Seitz, H. R., Heck, M., Hofmann, K. P., Alt, T., Pellaud, J. and Seelig, A. (1999) “Molecular determinants of the reversible membrane anchorage of the G-protein transducin”, Biochemistry, Vol. 38, H. 25, pp. 7950–7960.   edoc
 

Fischer, H., Seelig, A., Beier, N., Raddatz, P. and Seelig, J. (1999) “New drugs for the Na+/H+ exchanger : Influence of Na+ concentration and determination of inhibition constants with a microphysiometer”, The Journal of Membrane Biology, 168(1), pp. 39–45. 10.1007/s002329900496.   edoc | Open Access
 

Seelig, A. (1998) “How does P-glycoprotein recognize its substrates?”, International Journal of Clinical Pharmacology and Therapeutics, 36(1), pp. 50–54.   edoc
 

Fischer, H., Gottschlich, R. and Seelig, A. (1998) “Blood-brain barrier permeation : molecular parameters governing passive diffusion”, The Journal of Membrane Biology, 165(3), pp. 201–211. 10.1007/s002329900434.   edoc | Open Access
 

Seelig, A. (1998) “A general pattern for substrate recognition by P-glycoprotein”, European journal of biochemistry, Vol. 251, H. 1/2, pp. 252–261.   edoc
 

Wenk, M. R., Alt, T., Seelig, A. and Seelig, J. (1997) “Octyl-beta-D-glucopyranoside partitioning into lipid bilayers: thermodynamics of binding and structural changes of the bilayer”, Biophysical Journal, 72(4), pp. 1719–1731. 10.1016/S0006-3495(97)78818-0.   edoc
 

Dathe, M., Wieprecht, T., Seelig, A., Matsuzaki, K. and Bienert, M. (1996) “Antimikrobiell wirksame Peptide : zur Rolle der Primär- und Sekundärstruktur für die Peptid-Membran-Interaktion”, Nova acta Leopoldina. [Neue Folge]. Supplementum, Nr. 14, pp. 33–45.   edoc
 

Seelig, A. and Seelig, J. (1996) “Interaction of drugs and peptides with the lipid membrane”, in Structure and Function of 7TM Receptors. Copenhagen: Munksgaard, pp. 184–191.   edoc
 

Seelig, A., Alt, T., Lotz, S. and Holzemann, G. (1996) “Binding of substance P agonists to lipid membranes and to the neurokinin-1 receptor”, Biochemistry, Vol. 35, H. 14, pp. 4365–4374.   edoc
 

Hanakam, F., Gerisch, G., Lotz, S., Alt, T. and Seelig, A. (1996) “Binding of hisactophilin I and II to lipid membranes is controlled by a pH-dependent myristoyl-histidine switch”, Biochemistry, Vol. 35, H. 34, pp. 11036–11044.   edoc
 

Holzemann, G., Gotsmann, W., Greiner, H. and Seelig, A. (1994) “Surface activity measurements of NK-2 antagonists”, in Proceedings of the 5th Akabori Conference. München: Max-Planck-Gesellschaft, pp. 116–119.   edoc
 

Seelig, A., Gottschlich, R. and Devant, R. M. (1994) “A method to determine the ability of drugs to diffuse through the blood-brain barrier”, Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, H. 1, pp. 68–72.   edoc
 

Seelig, A., Alt, T., Kuerz, L. and Mutter, M. (1993) “The Gibbs Adsorption isotherm provides information on the secondary structure formation of amphiphilic peptides”, in Peptides 1992. Leiden: ESCOM, pp. 113–114.   edoc
 

Holzemann, G., Greiner, H. E., Harting, J., Barnickel, G. and Seelig, A. (1993) “Do substance P agonists insert into the lipid membrane?”, Regulatory Peptides, Vol. 46, H. 1-2, pp. 453–454.   edoc
 

Seelig, A. (1992) “Interaction of a substance P agonist and of substance P antagonists with lipid membranes : a thermodynamic analysis”, Biochemistry, Vol. 31, H. 11, pp. 2897–2904.   edoc
 

Mutter, M., Altmann, K. .-H., Buttkus, U., Gassmann, R., Kuerz, L. and Seelig, A. (1991) “Switch peptides : medium induced alpha-helix to beta-sheet transitions of bis-amphiphilic secondary structures and their membrane activity”, in Peptides. Leiden: ESCOM, pp. 344–345.   edoc
 

Seelig, A. and Doelz, R. (1991) “Substance P and antagonists : Surface activity, conformations, and lipid binding”, Annals of the New York Academy of Sciences, Vol. 632, pp. 468–470.   edoc
 

Seelig, A. (1990) “Substance P and antagonists : surface activity and molecular shapes”, Biochimica et biophysica acta, Vol. 1030, H. 1, pp. 111–118.   edoc
 

Seelig, A. (1990) “The use of monolayers for simple and quantitative analysis of lipid-drug interactions exemplified with dibucaine and substance P”, Cell Biology International Reports, Vol. 14, H. 4, pp. 369–380.   edoc
 

Seelig, A. and Macdonald, P. M. (1989) “Binding of a neuropeptide, substance P, to neutral and negatively charged lipids”, Biochemistry, Vol. 28, H. 6, pp. 2490–2496.   edoc
 

Seelig, A., Allegrini, P. R. and Seelig, J. (1988) “Partitioning of local anesthetics into membranes : surface charge effects monitored by the phospholipid head-group”, Biochimica et biophysica acta, Vol. 939, H. 2, pp. 267–276.   edoc
 

Seelig, A. (1987) “Local anesthetics and pressure : a comparison of dibucaine binding to lipid monolayers and bilayers”, Biochimica et biophysica acta, Vol. 899, H. 2, pp. 196–204.   edoc
 

Seelig, A. and Seelig, J. (1985) “Phospholipid composition and organization of cytochrome c oxidase preparations as determined by 31P-nuclear magnetic resonance”, Biochimica et biophysica acta, Vol. 815, H. 2, pp. 153–158.   edoc
 

Seelig, J., Seelig, A. and Tamm, L. (1982) “Nuclear magnetic resonance and lipid-protein interactions : a review”, in Lipid-Protein Interactions. New York: John Wiley (A Wiley-Interscience Publication), pp. 127–148.   edoc
 

Seelig, A., Ludwig, B., Seelig, J. and Schatz, G. (1981) “Copper and manganese electron spin resonance studies of cytochrome c oxidase from Paracoccus denitrificans”, Biochimica et biophysica acta, Vol. 636, H. 2, pp. 162–167.   edoc
 

Seelig, J. and Seelig, A. (1980) “Lipid conformation in model membranes and biological membranes”, Quarterly Reviews of Biophysics, 13(1), pp. 19–61. 10.1017/S0033583500000305.   edoc | Open Access
 

Zaccai, G., Buldt, G., Seelig, A. and Seelig, J. (1979) “Neutron diffraction studies on phosphatidylcholine model membranes : II. Chain conformation and segmental disorder”, Journal of molecular biology, Vol. 134, H. 4, pp. 693–706.   edoc
 

Buldt, G., Gally, H. U., Seelig, A., Seelig, J. and Zaccai, G. (1978) “Neutron diffraction studies on selectively deuterated phospholipid bilayers”, Nature, Vol. 271, pp. 182–184.   edoc
 

Seelig, A. and Seelig, J. (1978) “Lipid-protein interaction in reconstituted cytochrome c oxidase/phospholipid membranes”, Hoppe-Seyler’s Zeitschrift für physiologische Chemie, Vol. 359, H. 12, pp. 1747–1756.   edoc
 

Seelig, A. and Seelig, J. (1977) “Effect of a single cis double bond on the structures of a phospholipid bilayer”, Biochemistry, Vol. 16, H. 1, pp. 45–50.   edoc
 

Gally, H. U., Seelig, A. and Seelig, J. (1976) “Cholesterol-induced rod-like motion of fatty acyl chains in lipid bilayers a deuterium magnetic resonance study”, Hoppe-Seyler’s Zeitschrift für physiologische Chemie, Vol. 357, H. 10, pp. 1447–1450.   edoc